13th Century - First mention of
the "butterfly rashes" on the malar (above the cheeks) part of the
face.
13th Century - The term "Lupus"
which is Latin for wolf is attributed to Rogerius a physician who
used the term to describe the facial lesions that resembled the
bites and scratches made by a wolf's attack.
19th Century - Thomas Bateman,
Cazenave, and Moriz Kaposi describe the various dermatologic
features of Lupus.
1833 - Cazenave describes what
is now know as discoid lesions for the first time.
1846 - Von Hebra describes the
butterfly rash for the first time.
1856 - Von Hebra publishes the
first illustrations of Lupus Erythematosus in his Atlas of Skin
Disease.
1872 - Kaposi first describes
the systemic nature of the disease. He further suggests that
there are two types of Lupus, the discoid form and the disseminated
form.
1894 - Payne first discusses
the usefulness of quinine in treating Lupus.
1904 - The disseminated or
systemic form of Lupus are firmly established by the work of Osler
in Baltimore and Jadassohn in Vienna.
1908 - Alfred Kraus and Carl
Bohac describe "lupic pneumonia" recognizing lung involvement.
1923 - Emanuel Libman and
Benjamin Sacks recognize non-infectious
endocarditis.
1939 - Leukopenia and
hypersensitivity to sunlight are first described in cases of Lupus
Erythematosus.
1948 - Hargraves and colleagues
discover the LE cell resulting in the application of immunology to
the study of Lupus.
1948 - Phillip Hench discovers
cortisone providing the greatest therapy for Lupus to date.
1950s - Moore in Baltimore
first associate Lupus with the false positive syphilis test.
1951 -
Antimalarials are first
used in
Lupus
treatment.
1952 -
Immunosuppressives are
first used to
treat Lupus.
1954 - Leonhardt first
recognize familial
occurrence
of Lupus.
1954 - The Cleveland Clinic
first discover Drug-induced Lupus.
1955 - A derivative of
cortisone, prednisone, is synthesized.
1958 - Friou apply the
technique of using indirect immunofluorescence to demonstrate the
presence of antinuclear antibodies in the blood developing the
ANA test.
1971 - A committee of North
American rheumatologists meet to establish criteria for diagnosing
SLE.
1982 - The diagnostic criteria
are revised.
